Method for discriminating between live and dead microbes in a sample
US11542563B2 · kind B2 · utility
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Key dates
| Filing date | Oct 20, 2020 |
| Grant date | Jan 3, 2023 |
| Priority date | — |
| Expiry date | Oct 20, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2563/179
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for discriminating between live and dead microbes in a sample, by discriminating between transcriptionally-active and inert microbial nucleic acid sequences in the sample. In particular, the method is based on the comparison of levels of nucleotide substitution in a sample cultured in presence of an RNA-labelling agent. Also, a diagnosis method of microbial infections in a subject; and methods of assessing the risk of contamination of a sample, implementing the method for discriminating between live and dead microbes in a sample.
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