Aryl hydrocarbon receptor modulators

US11547698B2 · kind B2 · utility

Assignee

• ARIAGEN, INC. · US

Inventors

• Luqing Yang · Lo Wu, CN
• Guodong Li · Hornsby, AU
• Suoming Zhang · Shanghai, CN

Key dates

• Filing date: Dec 22, 2017
• Grant date: Jan 10, 2023
• Expiry date: Dec 22, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/044
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure discloses an aryl hydrocarbon receptor modulators of formula (I), and pharmaceutically acceptable salts, two Ra is independently H, or two Ra together form ═O or ═N—W3—R1; A is a C6 to C10 aromatic ring, or a C2 to C10 heteroaromatic ring containing 1 to 5 heteroatom from N, O and S, or 4 to 7 membered non-aromatic heterocyclic ring containing 1 to 3 heteroatom from N, O and S and C═N, which are with no substituent or substituted by 1 or 3 R; Q is R, or a C6 to C10 aromatic ring or a C2 to C10 heteroaromatic ring containing 1 to 5 heteroatom selected from N, O and S, which are with no substituent or substituted by 1 or 3 R; R is Rc connected with C or RN connected with N.