Replication stress pathway agent compositions and methods for treating cancer

US11547711B2 · kind B2 · utility

Assignee

• BOUNDLESS BIO, INC. · US

Inventors

• Christian A. Hassig · San Diego, US
• Ryan Hansen · Carmel, US
• Snezana Milutinovic · San Diego, US
• Jason Christiansen · Glastonbury, US
• Zachary D. Hornby · San Diego, US
• Sudhir CHOWDHRY · San Diego, US
• Anthony J. Celeste · Hudson, US
• Kristen Turner · San Diego, US
• Deepti Wilkinson · San Diego, US

Key dates

• Filing date: Jan 4, 2022
• Grant date: Jan 10, 2023
• Expiry date: Jan 4, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.