Patent · US Active

Means and methods for treating and diagnosing fibrosis or fibrosis-associated diseases

US11548934B2 · kind B2 · utility

0Cited by

2References

17Claims

0Family size

Assignee

Deutsches Krebsforschungszentrum · DE

Inventors

Amir Abdollahi · Heidelberg, DE
Kashi Javaherian · Heidelberg, DE
Jürgen Debus · Heidelberg, DE
Cheng Zhou · Shanghai, CN

Key dates

Filing date	Dec 5, 2016
Grant date	Jan 10, 2023
Priority date	—
Expiry date	Jul 12, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is concerned with a protein oligomer comprising (i) at least two NC-monomers of collagen 18 or (ii) at least two endostatin domains of collagen 18 or (iii) at least two N-terminal peptides of the collagen 18 endostatin domain, for use in treating, ameliorating or preventing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease. The invention further relates to the mentioned protein oligomer for use for detecting and/or diagnosing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.