Lyophilized pharmaceutical compositions for naked DNA gene therapy
US11554179B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 19, 2019 |
| Grant date | Jan 17, 2023 |
| Priority date | — |
| Expiry date | Jan 8, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a novel lyophilized pharmaceutical composition that maintains the stability of a DNA plasmid while forming a uniform and elegant cake during lyophilization. The novel lyophilization formulation further allows uniform reconstitution of the DNA plasmid in a pharmaceutically acceptable solution, enabling complete recover of the active ingredients, minimizing partial loss of potency and allowing administration of the active ingredients in an accurate and consistent manner. Additionally provided herein include methods of making the lyophilized pharmaceutical composition and methods of administering the composition for treatment of various diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.