Adeno-associated virus virions with variant capsid and methods of use thereof

US11554180B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• The Trustees of the University of Pennsylvania · US

Inventors

• David V. Schaffer · Danville, US
• John G. Flannery · Berkeley, US
• William A. Beltran · Philadelphia, US
• Leah C. Byrne · Berkeley, US
• Meike Visel · Corona, US

Key dates

• Filing date: Jul 27, 2017
• Grant date: Jan 17, 2023
• Expiry date: May 27, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14145
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.