Patent · US Active

Method for regenerating the interverterbral disc with notochordal cells

US11554195B2 · kind B2 · utility

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0References

9Claims

0Family size

Assignee

Cedars Sinai Medical Center · US

Inventors

Zulma Gazit · Los Angeles, US
Dmitriy Sheyn · Los Angeles, US
Gadi Pelled · Los Angeles, US
Dan Gazit · Modiin-Maccabim-Reut, IL

Key dates

Filing date	Jun 22, 2016
Grant date	Jan 17, 2023
Priority date	—
Expiry date	Jul 13, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/45
WIPO fieldMedical technology
WIPO sectorInstruments

Abstract

Described herein are compositions and methods related to derivation of human notochordal cells differentiated from induced pluripotent stem cells (iPSCs). The inventors have developed a two-step process for generating these iPSC-derived notochordal cells (iNCs), which can provide a renewable source of therapeutic material for use in degenerative disc disease (DDD). As iNCs are capable of reversing DDD and supporting regeneration of intervertebral disc (IVD) tissue based on the understanding that NC cells maintain homeostasis and repair of other IVD cell types such as nuclear pulposus (NP).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.