Full continuous flow preparation method of 2-methyl-4-amino-5-aminomethylpyrimidine
US11554356B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 3, 2021 |
| Grant date | Jan 17, 2023 |
| Priority date | — |
| Expiry date | Sep 3, 2041 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00963
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A full continuous flow preparation method of 2-methyl-4-amino-5-aminomethylpyrimidine. A mixed solution of cyanoacetamide, N,N-dimethylformamide and a catalyst is mixed with phosphorus oxychloride in a first micro-mixer, and then the reaction mixture undergoes continuous flow reaction in a microchannel reactor to obtain (dimethylaminomethylene) malononitrile. The reaction mixture is subjected to continuous quenching, extraction and separation, and the organic phase is concentrated, mixed with a methanol solution, and then reacted with an organic base to obtain 2-methyl-4-amino-5-cyanopyrimidine. After the mixed liquid is continuously filtered, the filter cake is dissolved in methanol, mixed with hydrogen in a second micro-mixer, and then transported to a fixed-bed reactor for hydrogenation reaction. The products are concentrated, dried and purified to obtain the desired 2-methyl-4-amino-5-aminomethylpyrimidine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.