Pumpless microfluidic organ-on-a-chip system including a functional immune system
US11554373B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Dec 29, 2017 |
| Grant date | Jan 17, 2023 |
| Priority date | — |
| Expiry date | Sep 17, 2039 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0877
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A pumpless microfluidic system is disclosed that can be used to mimic the interaction of organ systems with the immune system. Also disclosed is a method for mimicking an immune system, comprising culturing a plurality of organ cells and at least one population of immune cells in the disclosed pumpless microfluidic system under physiological conditions. The method can further comprise activating an immune reaction in the pumpless microfluidic system, continuing the culture for a defined period, collecting a sample of culture medium from the system, and assaying the sample for one or more indicators of an immune response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.