2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof

US11555009B2 · kind B2 · utility

Assignee

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Caiguang Yang · Shanghai, CN
• Yue Huang · Midlothian, US
• Ze Dong · Morristown, US
• Tao Zhang · Beijing, CN
• Hongjiao Xu · Shanghai, CN

Key dates

• Filing date: Mar 1, 2018
• Grant date: Jan 17, 2023
• Expiry date: Mar 1, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides 2-(substituted phenylhetero) aromatic formate FTO inhibitors, a preparation method thereof, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted phenylhetero) aromatic formate compound represented by the following formula (I), and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, which can be used as an FTO targeting inhibitor for treating diseases associated with FTO targets, including obesity, metabolic syndrome (MS), type 2 diabetes (T2D), Alzheimer's diseases, and cancers such as breast cancers, small-cell lung cancers, human bone marrow rhabdomyosarcoma, pancreatic cancer, malignant glioblastoma and the like.