Patent · US Active

4-1BB antibody and preparation method and use thereof

US11555077B2 · kind B2 · utility

0Cited by

2References

12Claims

0Family size

Assignee

Shanghai Hyamab Biotech Co., Ltd. · CN

Inventors

Heng Pan · Lianyungang, CN
Haohan Liu · Shanghai, CN
Yingying Gao · Shanghai, CN
Shaoping HU · Shanghai, CN
Yong Li · Corvallis, US
Mingming PAN · Shanghai, CN
Tatchi Teddy YANG · Shanghai, CN
Qing DUAN · Shanghai, CN
Lile LIU · Shanghai, CN

Key dates

Filing date	Nov 8, 2018
Grant date	Jan 17, 2023
Priority date	—
Expiry date	May 4, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/33
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided in the present invention are a 4-1BB antibody and a preparation method and the use thereof. In particular, provided in the present invention are a 4-1BB antibody, which has high affinity to 4-1BB protein, can effectively activate the signal downstream of the 4-1BB and significantly increase expression quantities of IFN-γ and IL-2 in human mixed lymphocytes or T lymphocytes, and can be used to treat cancers and autoimmune diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.