Conjugates of active pharmaceutical ingredients

US11559585B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Yuanpei Li · Davis, US
• Xiangdong XUE · Davis, US
• Yee HUANG · Davis, US
• Zhao Ma · Xi'an, CN

Key dates

• Filing date: Jun 15, 2018
• Grant date: Jan 24, 2023
• Expiry date: Jun 15, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N23/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.