Methods for preparing particles and related compositions
US11564893B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 17, 2016 |
| Grant date | Jan 31, 2023 |
| Priority date | — |
| Expiry date | Aug 17, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for preparing particles and related compositions are provided. In some embodiments, the particles include at least one polynucleotide (e.g., mRNA), and in certain embodiments, the particles may include at least one ionizable molecule (e.g., a lipid). A method for preparing a suspension including the particles may comprise one or more filtration steps. In some such embodiments, prior to or during filtration, one or more properties of the particles (e.g., surface charge) and/or one or more properties of the suspension (e.g., pH) may be altered. In some embodiments, altering one or more properties of the particles and/or suspension may improve yield, improve a characteristic of the resulting composition, and/or prevent or reduce certain problems, such as fouling during the filtration process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.