Tumor-delivered multi-target therapeutics for colon cancer
US11564954B2 · kind B2 · utility
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Key dates
| Filing date | Feb 20, 2020 |
| Grant date | Jan 31, 2023 |
| Priority date | — |
| Expiry date | Feb 20, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/42
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to genetically modified strains of Salmonella, engineered to be tumor navigating, self-eradicating, and armed with decoy polypeptides that bind endogenous ligand and block activation of signal transduction cascades associated with cancer cell proliferation and tumor growth. Also provided herein are methods of producing and methods of using such genetically modified Salmonella strains to treat cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.