3-(5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

US11566022B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Simone BONAZZI · Cambridge, US
• Artiom CERNIJENKO · Cambridge, US
• Jennifer Stroka Cobb · Stow, US
• Natalie Dales · Arlington, US
• John Ryan Kerrigan · Wakefield, US
• Philip Lam · Somerville, US
• Hasnain Ahmed Malik · Boston, US
• Gary O'Brien · Maynard, US
• Andrew W. Patterson · Somerville, US
• Noel Marie-France Thomsen · Cambridge, US
• Pamela YF TING · Somerville, US

Key dates

• Filing date: Dec 16, 2020
• Grant date: Jan 31, 2023
• Expiry date: Apr 21, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to compounds of formula (I′) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders, including hemoglobinopathies, sickle cell disease and beta-thalassemia.