Process for the preparation of high purity glucagon
US11566058B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Jun 18, 2020 |
| Grant date | Jan 31, 2023 |
| Priority date | — |
| Expiry date | Jun 18, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an improved process for the preparation of high purity glucagon comprising the use of Xmb-protected amino acids, wherein may Xmb include, e.g., 2,4,6-trimethoxybenzyl, 2,4-dimethoxybenzyl, or 2-hydroxy-4-methoxybenzyl. The process also comprises the use of building blocks such as pseudoprolines to avoid aggregation and obtain the product in high yield and purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.