γδ T cell expansion procedure
US11566222B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Dec 18, 2019 |
| Grant date | Jan 31, 2023 |
| Priority date | — |
| Expiry date | Dec 12, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/11
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for expanding a population of γδ T-cells is provided in which isolated activated Peripheral Blood Mononuclear Cells (PBMCs) are cultured in a medium comprising transforming growth factor beta (TGF-β) under conditions in which the production of effector γδ T-cells having therapeutic activity against malignant disease is favored. The use of TGF-β in the production of effector cells in particular Vγ9Vδ2 T-cells is also described and claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.