Patent · US Active

Method of predicting the likelihood of success of gene therapy

US11567064B2 · kind B2 · utility

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21Claims
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Inventor

Key dates

Filing dateSep 27, 2017
Grant dateJan 31, 2023
Priority date—
Expiry dateJan 30, 2040

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2800/52
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A method of predicting the likelihood of success of a gene therapy procedure includes inducing DNA damage in a cell sample from an individual. The ability of the individual's cells in the sample to repair the DNA damage is then assessed to determine whether the individual could tolerate DNA damage caused by a gene therapy vector. In preferred embodiments, the ability of the individual's cells to repair DNA damage is assessed by detecting, and monitoring the subsequent disappearance of, a marker of DNA damage repair (such as gamma H2AX or phosphorylated 53BP1) in the sample.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.