Removal of homogeneous catalysts from NMR/MRI agents hyperpolarized via sabre or PHIP

US11571686B2 · kind B2 · utility

Assignees

• Board of Trustees of Southern Illinois University · US
• VANDERBILT UNIVERSITY · US
• The Regents of the University of California · US

Inventors

• Boyd Goodson · Berkeley, US
• Eduard Y. Chekmenev · Brentwood, US
• Igor V. Koptyug · Novosibirsk, RU
• Kirill V. Kovtunov · Novosibirsk, RU
• Roman V. Shchepin · Nashville, US
• Bryce E. Kidd · Carbondale, US
• Jonathan Gesiorski · Hickory Hills, US
• Max E. Gemeinhardt · Carbondale, US
• Danila A. Barskiy · Berkeley, US

Key dates

• Filing date: Feb 17, 2020
• Grant date: Feb 7, 2023
• Expiry date: Feb 27, 2041

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2531/827
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.