Antibacterial agents: arylalkylcarboxamido phloroglucinols

US11572337B2 · kind B2 · utility

Assignee

• Rutgers, the State University of New Jersey · US

Inventors

• Richard H. Ebright · New Brunswick, US
• Yon W. Ebright · New Brunswick, US
• Joel Freundlich · Princeton, US
• Ricardo Gallardo-Macias · New Brunswick, US
• Shao gang Li · New Brunswick, US

Key dates

• Filing date: Mar 6, 2019
• Grant date: Feb 7, 2023
• Expiry date: Mar 6, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula (I) or (II) and tautomers and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula (I) or (II) or a tautomer or salt thereof, methods of making a compound of formula (I) or (II) or a tautomer or salt thereof, and methods of using a compound of formula (I) or (II) or a tautomer or salt thereof as, e.g., inhibitors of bacterial RNA polymerase or as antibacterial agents.