Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof
US11572354B2 · kind B2 · utility
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Key dates
| Filing date | Jan 9, 2019 |
| Grant date | Feb 7, 2023 |
| Priority date | — |
| Expiry date | Jan 9, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of Formula (Ia) and (Ib) of IDO, their synthesis, and uses thereof are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.