Method for promoting diversification of antibody variable region
US11572402B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Feb 9, 2018 |
| Grant date | Feb 7, 2023 |
| Priority date | — |
| Expiry date | Jul 15, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/24
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for promoting diversification of variable regions of an antibody. Specifically, the present invention relates to a method for promoting diversification of the amino acid sequences of variable regions of an antibody generated by an avian B cell population, wherein the method comprises suppressing the PI3Kα activity of each avian B cell comprised in the avian B cell population expressing the antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.