Multivalent FV antibodies

US11572415B2 · kind B2 · utility

Assignee

• AFFIMED GMBH · DE

Inventors

• Kristina Ellwanger · Heidelberg, DE
• Ivica Fucek · Hattersheim, DE
• Thorsten Ross · Edingen-Neckarhausen, DE
• Thomas Mueller · Hersbruck, DE
• Erich Rajkovic · Schriesheim, DE
• Uwe Reusch · Maikammer, DE
• Martin Treder · Heidelberg, DE
• Michael Weichel · Bischofsheim, DE

Key dates

• Filing date: Apr 11, 2018
• Grant date: Feb 7, 2023
• Expiry date: Jul 6, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/626
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The application pertains to a trispecific antibody molecule which may comprise a diabody-unit integrated into a polypeptide chain having at least six variable domains linked one after another. In certain instances two single-chain Fv (scFv) fragments are distally connected to the diabody-unit providing two further antigen binding sites (FIGS. 1 and 2).