Methods for generating an image of a biological sample

US11573235B2 · kind B2 · utility

Assignee

• LEICA MICROSYSTEMS CMS GMBH · DE

Inventors

• Antti Seppo · The Bronx, US
• Fiona Ginty · Niskayuna, US
• Kevin Bernard Kenny · Niskayuna, US
• David L. Henderson · Austin, US
• Michael John Gerdes · Albany, US
• Adriana Ines Larriera · Niskayuna, US
• Xiaofeng Liu · Niskayuna, US
• Alex David Corwin · Niskayuna, US
• Stephen Eric Zingelewicz · Niskayuna, US
• Thomas Ha · Aliso Viejo, US
• Natalia R. JUN · Aliso Viejo, US
• Ainura Kyshtoobayeva · Aliso Viejo, US
• Denise A. Hollman-Hewgley · Aliso Viejo, US
• Ying Li · Niskayuna, US

Key dates

• Filing date: Mar 21, 2013
• Grant date: Feb 7, 2023
• Expiry date: Jul 22, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30096
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for generating an image of a region of interest in a biological sample comprising the steps of: generating a first image including the region of interest of the biological sample having undergone a first protocol but not a second protocol; and generating a second image including the region of interest of the biological sample after having undergone a second protocol; wherein the region of interest is smaller than said sample. Also provided is a method of analyzing a biological sample, comprising providing an image of the biological sample according to the method for generating an image of a region of interest in a biological sample, and analyzing the biological sample from the image. Further provided are system and kit that comprise the means for executing the novel methods.