Mutant Nicotiana benthamiana plant or cell with reduced XylT and FucT

US11576317B2 · kind B2 · utility

Assignees

• CELLECTIS SA · FR
• MEDICALIP CO., LTD. · DE

Inventors

• Luc Mathis · Le Kremlin-Bicêtre, FR
• Daniel F. Voytas · Falcon Heights, US
• Jin Li · Shoreview, US
• Feng Zhang · Cambridge, US
• Thomas Stoddard · St. Louis Park, US
• Marc-Andre D'Aoust · Keyano, CA

Key dates

• Filing date: Nov 13, 2020
• Grant date: Feb 14, 2023
• Expiry date: Jun 14, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P21/005
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.