Hepatitis C virus immunogenic compositions and methods of use thereof

US11576968B2 · kind B2 · utility

Assignee

• The Governors of the University of Alberta · CA

Inventors

• Michael Houghton · Berkeley, US
• Abdolamir Landi · Edmonton, CA
• Carlos Guzman · Wolfenbüttel, DE
• Thomas Ebensen · Hannover, DE
• Darren Hockman · Edmonton, CA
• John L. Law · Edmonton, CA
• Michael Logan · Edmonton, CA

Key dates

• Filing date: Dec 15, 2020
• Grant date: Feb 14, 2023
• Expiry date: Jun 15, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/24234
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.