Chemical process for preparing phenylpiperidinyl indole derivatives

US11578053B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Peng-Fei Fu · Midland, US
• Yu Gai · Hoherlehmer Straße, CN
• Feng Gao · Beijing, CN
• Weiyong Kong · Suzhou, CN
• Yadong Lu · Hoherlehmer Straße, CN
• Zhongcheng Min · Shuozhou, CN
• Shaofeng RONG · Hoherlehmer Straße, CN
• Chutian Shu · Jinan, CN
• Can Wang · Suzhou, CN
• Ruidong WANG · Beijing, CN
• Jibin Zhao · Suzhou, CN
• Xianglin Zhao · Shanghai, CN
• Yi Zhao · South Pasadena, US
• Jianguang Zhou · 林湖乡, CN
• Benjamin Martin · Clermont-Ferrand, FR

Key dates

• Filing date: Dec 9, 2021
• Grant date: Feb 14, 2023
• Expiry date: Dec 9, 2041

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.