Matrix arrays and methods for making same

US11578356B2 · kind B2 · utility

Assignee

• Life Technologies Corporation · US

Inventors

• David Light · Branford, US
• Wolfgang Hinz · Killingworth, US
• Ronald L. Cicero · Palo Alto, US
• Christina E. Inman · San Mateo, US
• Paul Kenney · Sunnyvale, US
• Alexander Mastroianni · Alameda, US
• Roman Rozhkov · Carlsbad, US
• Yufang Wang · Nanhu, CN
• Jeremy Gray · Larkspur, US
• Marc Glazer · Sunnyvale, US
• Dmitriy Gremyachinskiy · San Francisco, US

Key dates

• Filing date: Jul 24, 2020
• Grant date: Feb 14, 2023
• Expiry date: Apr 16, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6874
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method of forming a polymer matrix array includes treating a surface within a well of a well array with a surface compound including a surface reactive functional group and a radical-forming distal group; applying an aqueous solution including polymer precursors to the well of the well array; and activating the radical-forming distal group of the surface coupling compound with an initiator and atom transfer radical polymerization (ATRP) catalyst to initiate radical polymerization of the polymer precursors within the well of the well array to form the polymer matrix array.