Aptamer-based sensors for detection of fentanyl opioids
US11579110B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 27, 2022 |
| Grant date | Feb 14, 2023 |
| Priority date | — |
| Expiry date | May 27, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/13
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The subject invention provides materials and methods for single-step fluorescence and electrochemical detection of small molecules, e.g., fentanyl and its analogs, in a sample. The subjection invention provides nucleic acids materials, e.g., aptamers (nucleic acid oligonucleotides) that can bind to fentanyl and its analogs with nanomolar affinity and high specificity against illicit drugs, adulterants, and cutting agents commonly existing in seized samples. The method for detecting fentanyl and/or its analogs in a sample comprises contacting the sample with an aptamer-based sensor selective for fentanyl and its analogs, and sensitively, specifically, and rapidly detecting fentanyl and/or its analogs in the sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.