Stabilized formulations of lipid nanoparticles
US11583504B2 · kind B2 · utility
10Cited by
69References
25Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 8, 2017 |
| Grant date | Feb 21, 2023 |
| Priority date | — |
| Expiry date | Nov 8, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure features a lipid nanoparticle (LNP) formulation comprising a plurality of LNPs and a stabilizing agent that mitigates the degradation of the LNPs or a subpopulation thereof. Lipid nanoparticles further including therapeutics and/or prophylactics such as RNA are useful in the delivery of therapeutics and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression. Methods of manufacturing LNP formulations and screening for a stabilizing agent are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.