Patent · US Active

Treating progressive familial intrahepatic cholestasis (PFIC) with IBAT inhibitors

US11583539B2 · kind B2 · utility

8Cited by

77References

29Claims

0Family size

Assignee

ALBIREO AB · SE

Inventors

Per-Göran Gillberg · Timrå, SE
Jan Mattsson · Gothenburg, SE
Pat Horn · Boston, US
Paresh Soni · Mystic, US

Key dates

Filing date	Dec 10, 2021
Grant date	Feb 21, 2023
Priority date	—
Expiry date	Dec 10, 2041

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P17/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are methods for treating progressive familial intrahepatic cholestasis (PFIC) with an ileal bile acid transport (IBAT) inhibitor such as odevixibat, or a pharmaceutically acceptable salt thereof. Such methods can include reducing mean pruritus score, mean serum bile acid concentration, increasing height, normalizing weight, improving sleep, and improving liver parameters.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.