PSMA-targeting amanitin conjugates

US11583569B2 · kind B2 · utility

Assignee

• Heidelberg Pharma Research GmbH · DE

Inventors

• Francesca Gallo · Ladenburg, DE
• Barbara Korsak · Ladenburg, DE
• Christoph Mueller · Birkenau, DE
• Torsten Hechler · Ladenburg, DE
• Andreas Pahl · Ladenburg, DE
• Michael Kulke · Ladenburg, DE
• Werner Simon · Seeheim-Jugenheim, DE
• Christian Lutz · Kassel, DE

Key dates

• Filing date: Sep 24, 2018
• Grant date: Feb 21, 2023
• Expiry date: Sep 24, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a PSMA-targeting conjugate comprising (a) an amatoxin; (b) a small molecule PSMA-targeting moiety; and (c) optionally a linker linking said amatoxin and said small molecule PSMA-targeting moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.