Plasmodium falciparum recombinanr xiexumapoeozoite protein compositions and method for vaccine delivery

US11583578B2 · kind B2 · utility

Assignees

• The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. · US
• The Government of the United States, as represented by the Secretary of the Army · US

Inventors

• Sheetij Dutta · Silver Spring, US
• Zoltan Beck · Rockville, US
• Carl R. Alving · Bethesda, US
• Gary R. Matyas · Olney, US

Key dates

• Filing date: Apr 27, 2018
• Grant date: Feb 21, 2023
• Expiry date: Jul 12, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.