Spirocyclic compounds

US11584748B2 · kind B2 · utility

Assignee

• C4 THERAPEUTICS, INC.

Inventors

• Christopher G. Nasveschuk · Stoneham, US
• Fabian Dey · Basel, CH
• Annick Goergler · Basel, CH
• Bernd Kuhn · Sursee, CH
• Roger Norcross · Olsberg, CH
• Stephan Roever · Inzlingen, DE
• Philipp Schmid · Basel, CH

Key dates

• Filing date: Oct 16, 2020
• Grant date: Feb 21, 2023
• Expiry date: Oct 16, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.