Near-infrared fluorescent indicators for lysosome and application thereof
US11584762B1 · kind B1 · utility
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Key dates
| Filing date | Jul 26, 2022 |
| Grant date | Feb 21, 2023 |
| Priority date | — |
| Expiry date | Jul 26, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/64
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure relates to Near-infrared fluorescent indicators for lysosomes and application thereof. These indicators are composed of lipophilic NIR BODIPY derivatives and ionizable bis-tertiary amine moiety, which enable the formation of a transient amphiphilic state in acidic environments specifically. This structural feature affords accurate lysosomal membrane targeting ability at nanomole staining concentration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.