Patent · US Active

C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses

US11584775B2 · kind B2 · utility

0Cited by

59References

10Claims

0Family size

Assignee

REATA PHARMACEUTICALS HOLDINGS, LLC · US

Inventors

Melean Visnick · Irving, US
Xin Jiang · Coppell, US
Martha R. HOTEMA · Hurst, US
Chitase Lee · Ann Arbor, US
Bradley W. Caprathe · Redford, US
William H. Roark · Ann Arbor, US
Gary L. Bolton · Ann Arbor, US

Key dates

Filing date	Sep 23, 2016
Grant date	Feb 21, 2023
Priority date	—
Expiry date	Sep 23, 2036

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.