Non-standard amino acid containing compositions and uses thereof
US11584921B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Jan 8, 2021 |
| Grant date | Feb 21, 2023 |
| Priority date | — |
| Expiry date | Jan 8, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/21001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein is a stabilized DNase I polypeptide containing a non-standard amino acid that maintains enzymatic activity even under harsh conditions, such as reducing environments. The stabilized DNase I polypeptide has enzymatic activity in reducing environments that is higher than a corresponding DNase I polypeptide without the non-standard amino acids under the same conditions. Also provided herein are polynucleotides encoding the stabilized DNase I polypeptide, cells for expressing and/or producing the stabilized DNase I polypeptide, and methods of use of the stabilized DNase I polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.