Compositions and methods for improving immune system function

US11584934B2 · kind B2 · utility

Assignee

• Tufts Medical Center, Inc. · US

Inventors

• Richard P. Junghans · Boston, US
• Mumtaz Yaseen · Boston, US

Key dates

• Filing date: Jul 14, 2017
• Grant date: Feb 21, 2023
• Expiry date: Jun 12, 2040

Classification

• Technology area (CPC —): General

Abstract

Provided herein are compositions and methods for improving immune system function. In particular, provided herein are compositions, methods, and uses of YY1 and EZH2 inhibitors for preventing and reversing T-cell exhaustion (e.g., for use in immunotherapy).