Superparamagnetic particle imaging and its applications in quantitative multiplex stationary phase diagnostic assays
US11585882B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 9, 2019 |
| Grant date | Feb 21, 2023 |
| Priority date | — |
| Expiry date | Dec 5, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/302
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics. The present invention also provides the hybrid point of care chip and analyzer to be used in the analytical method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.