Patent · US Active

Nano-fibular nanoparticle polymer-drug conjugate for sustained dermal delivery of retinoids

US11590240B2 · kind B2 · utility

0Cited by

2References

21Claims

0Family size

Assignee

Massachusetts Institute of Technology · US

Inventors

Steven A. Castleberry · Cambridge, US
Mohiuddin Quadir · Malden, US
Paula T. Hammond · Newton, US

Key dates

Filing date	Jun 23, 2016
Grant date	Feb 28, 2023
Priority date	—
Expiry date	Jun 23, 2036

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically acceptable salt thereof, and methods of using same to treat certain disorders. In an embodiment, the conjugated polymer comprises poly (vinyl alcohol) covalently bound to ATRA through an ester linkage.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.