Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors

US11591336B2 · kind B2 · utility

Assignees

• D.E Shaw Research, LLC. · US
• Relay Therapeutics, Inc. · US

Inventors

• Alexander M. Taylor · Cambridge, US
• Andre Lescarbeau · Somerville, US
• Elizabeth H. Kelley · Cambridge, US
• Kelley C. Shortsleeves · Maynard, US
• Lucian V. DiPietro · Gloucester, US
• W. Patrick Walters · Westborough, US
• Mark A. Murcko · Holliston, US
• Levi Charles Thomas Pierce · Somerville, US
• Yong Tang · Cambridge, US
• Fabrizio Giordanetto · New York, US
• Jack Benjamin Greisman · New York, US
• Paul Maragakis · New York, US
• Sathesh Bhat · Jersey City, US
• Markus Dahlgren · Stratford, US
• Eric Therrien · The Bronx, US

Key dates

• Filing date: May 25, 2018
• Grant date: Feb 28, 2023
• Expiry date: May 25, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.