FcRn-targeted mucosal vaccination against influenza infections

US11591371B2 · kind B2 · utility

Assignee

• UNIVERSITY OF MARYLAND, COLLEGE PARK · US

Inventors

• Xiaoping Zhu · 余新镇, CN
• Susan Park-Ochsner · Towson, US
• Weizhong Li · College Park, US

Key dates

• Filing date: Apr 2, 2019
• Grant date: Feb 28, 2023
• Expiry date: Apr 2, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); an influenza HA protein; and a trimerization domain. Disclosed are compositions comprising one or more of the peptides described herein. Disclosed are nucleic acid sequences capable of encoding any one of the peptides described herein. Disclosed are methods for eliciting a protective immune response against influenza comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; an influenza HA protein; and a trimerization domain, wherein the administering is to a mucosal epithelium. Disclosed are methods of treating a subject exposed to influenza or at risk of being exposed to influenza comprising administering to the subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; an influenza HA protein; and a trimerization domain, wherein the administering is to a mucosal epithelium.