Nucleic acids encoding anti-PAR2 antibodies and uses thereof

US11591389B2 · kind B2 · utility

Assignee

• MedImmune Limited · US

Inventors

• Claire Louise Dobson · Cambridge, GB
• Richard B. Williams · South Pasadena, US
• Ian Gurrell · Cambridge, GB
• Sadhana Podichetty · Cambridge, GB
• David Fairman · Cambridge, GB
• Peter Thornton · Los Altos, US
• Philip Newton · Cambridge, GB

Key dates

• Filing date: Sep 29, 2020
• Grant date: Feb 28, 2023
• Expiry date: Jul 15, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.