Retroviral and lentiviral vectors
US11591613B2 · kind B2 · utility
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2References
7Claims
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Key dates
| Filing date | Aug 16, 2017 |
| Grant date | Feb 28, 2023 |
| Priority date | — |
| Expiry date | Mar 12, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/859
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a retroviral or lentiviral vector having a viral envelope which comprises a mitogenic T-cell activating transmembrane protein which comprises: (i) a mitogenic domain which binds a mitogenic tetraspanin, and (ii) a transmembrane domain; wherein the mitogenic T-cell activating transmembrane protein is not part of a viral envelope glycoprotein. When cells such as T-cells or Natural Killer cells are transduced by such a viral vector, they are activated by the mitogenic T-cell activating transmembrane protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.