Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses
US11596635B2 · kind B2 · utility
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13References
12Claims
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Assignee
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Key dates
| Filing date | Nov 13, 2018 |
| Grant date | Mar 7, 2023 |
| Priority date | — |
| Expiry date | Sep 15, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.