Methods of treating nonalcoholic steatohepatitis comprising administering an anti-human beta klotho antibody or binding fragment thereof

US11596676B2 · kind B2 · utility

Assignee

• NGM Biopharmaceuticals, Inc. · US

Inventors

• Kalyani Mondal · San Mateo, US
• Betty Chan Li · Millbrae, US
• Yu Chen · Foster City, US
• Taruna Arora · Palo Alto, US
• Hugo Matern · San Mateo, US
• Wenyan Shen · Redwood City, US

Key dates

• Filing date: Jul 14, 2020
• Grant date: Mar 7, 2023
• Expiry date: Jul 30, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/66
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides binding proteins, such as antibodies and binding fragments thereof, that bind beta klotho, including human beta klotho, and methods of their use, including in the treatment of nonalcoholic steatohepatitis. The present disclosure also provides exemplary specific sequences of complementarity determining regions, variable regions, heavy chains, and light chains of the antibodies and/or binding fragments thereof.