Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6 expressing epithelial stem cells
US11596714B2 · kind B2 · utility
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Key dates
| Filing date | Apr 19, 2022 |
| Grant date | Mar 7, 2023 |
| Priority date | — |
| Expiry date | Apr 19, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2513/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.