Integrin ligands and uses thereof

US11597701B2 · kind B2 · utility

Assignee

• Arrowhead Pharmaceuticals, Inc. · US

Inventors

• Zhen Li · Westfield, US
• Xiaokai Li · Middleton, US
• Erik W. Bush · Verona, US
• Rui Zhu · Middleton, US
• Dongxu Shu · Madison, US
• Jonathan D. Benson · Stoughton, US
• Patrick Shao · Fanwood, US
• Matthew Fowler-Watters · Madison, US

Key dates

• Filing date: Oct 31, 2018
• Grant date: Mar 7, 2023
• Expiry date: Oct 31, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic αvβ6 integrin ligands of Formula I having serum stability and affinity for integrin αvβ6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin αvβ6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include αvβ6 integrin ligands and methods of use are also described.