Nicotine degrading enzyme variants

US11597916B2 · kind B2 · utility

Assignees

• ANTIDOTE THERAPEUTICS, INC. · US
• The Board of Regents of the University of Texas System · US

Inventors

• Matthew W. KALNIK · Bethesda, US
• Thomas Thisted · New Market, US
• Everett Stone · Austin, US
• Charles C. Reed · Souderton, US
• Max RODNICK-SMITH · Austin, US

Key dates

• Filing date: Feb 2, 2018
• Grant date: Mar 7, 2023
• Expiry date: Jan 14, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/0004
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are nicotine-degrading enzyme variants that exhibit increased nicotine-degrading activity and/or decreased immunogenicity relative to the wild-type NicA2 and NOX enzymes, compositions comprising the variants, and methods using them.