Use of inosine for the treatment of t-reg deficiency
US11602551B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | May 26, 2017 |
| Grant date | Mar 14, 2023 |
| Priority date | — |
| Expiry date | Feb 21, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides the use of inosine in the treatment of a disease associated with Treg deficiency or Treg dysfunction, in particular immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX). In one embodiment of the invention, the inosine can be provided in the form of a bacterial strain that is capable of stimulating the production of inosine. Methods for stimulating the production of inosine in a subject using said strains are also provided, as are methods for the selection of a bacterial strain capable of stimulating inosine production in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.